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Genetic Variation

Lesson 6: Page 2 of 17

Clinical Applications of Genomics : Genetic Variation

This lesson presents a discussion of:

  • The basic concepts of genetic variations in the DNA sequence;
  • How those variations may be detected;
  • How detecting variations can be applied to disease prevention and treatment;
  • The interactions of genes with drugs (pharmacokinetics and pharmacodynamics);
  • Sex-specific considerations in the applications of genomics; and
  • The steps needed to translate gene-based clinical tools into practice.

Lesson Six Learning Objectives

Upon completing this lesson, the participant will be able to:

  • Describe the basic concept of genetic variation
  • Explain the difference between inherited and acquired genetic variation
  • Describe the types of methods for detecting genetic variation
  • Explain how gene-based information may be used for prevention and treatment of diseases
  • Give examples of how genes can influence the effect of clinical drugs
  • Give examples of potential applications of pharmacogenomics
  • Describe sex-specific considerations in the applications of genomics
  • Understand the important issues involved in the translation of gene-based tools into clinical practice